Author's response to reviews Title: Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice Authors:
نویسندگان
چکیده
Alexander C Langheinrich ([email protected]) Marian Kampschulte ([email protected]) Franziska Scheiter ([email protected]) Christian Dierkes ([email protected]) Philip Stieger ([email protected]) Rainer M Bohle ([email protected]) Wolfgang Weidner ([email protected])
منابع مشابه
Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice
BACKGROUND The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney alterations in these mice. METHODS Kidneys from apoE-/-/LDL-/- double knockout mice at the age of 80 weeks (n = 6) and C57/BL control mice (n = 5) were infused with Microfil, harv...
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OBJECTIVE We hypothesized that apolipoprotein E (apoE)(-/-)/low-density lipoprotein (LDL)(-/-) double knockout mice might develop vasa vasorum (VV) in association with advanced lesion formation. METHODS AND RESULTS Aortas from apoE(-/-)/LDL(-/-) mice aged 16, 18, 20, or 80 weeks were infused in situ with Microfil, harvested, and scanned with micro-computed tomography (CT). We characterized pl...
متن کاملHuman apoE is present on nearly all serum lipoproteins and plays a protective role in atherosclerosis by acting both as a ligand for receptor-mediated lipoprotein clearance and as an acceptor for cholesterol exported by peripheral cells
Journal of Lipid Research Volume 55, 2014 2073 Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc. Human apoE is present on nearly all serum lipoproteins and plays a protective role in atherosclerosis by acting both as a ligand for receptor-mediated lipoprotein clearance and as an acceptor for cholesterol exported by peripheral cells ( 1, 2 ). apoE on triglycer...
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تاریخ انتشار 2010